Croscarmellose Sodium Cel-Ca-Dissol®
Cellulose Acting as a Catalyst for Dissolution
Modified Sodium Carboxy Methyl Cellulose
Crosslinked Sodium Carboxy Methyl Cellulose
As importance of bio-availability and fast disintegration of pharmaceutical tablet is realised, awarness for super-disintegrants in pharmaceutical tablet formulation is also increasing . Superdisintegrant viz. Sodium Starch Glycollate was also introduced by Maple Biotech Pvt Ltd. in year 1991, which was appreciated in quality and performance by pharmaceutical industry . Although quest for superior quality superdisintegrant was not over . Superdisintegrant with better stability and superior performance at high tablet hardness level was sought and Maple Biotech’s R & D department developed the product Crosslinked Sodium Carboxy Methyl Cellulose which is bearing brand name Cel-Ca-Dissol.
PROPERTIES
Cel-Ca-Dissol is white or creamish white in colour and chemically it is cross-linked Sodium Carboxy Methyl Cellulose with very high degree of purity. Very hard tablets where other superdisintegrants do not perform well Cel-Ca-Dissol performs very much satisfactorily. Quantity to be used in pharmaceutical formulation is very less. Cel-Ca-Dissol is required almost half the amount of other brands of Crosslinked Sodium Carboxy Methyl Cellulose to acheive similiar performance of tablet dissolution
ADVANTAGES
- good water uptake
- high capillary action
- rapid swelling properties
- efficient fluid channeling compatibility with most actives and excipients
- excellent long-term stability
- low usage level
- low cost-in-use
- very fast drug dissolution
